Stevens–Johnson syndrome/toxic epidermal necrolysis caused by cefadroxil in a cat

摘要: Case summaryA 5-year-old, spayed female, indoor-only domestic shorthair cat was referred with an acute history of multifocal cutaneous and mucocutaneous erosive-ulcerative lesions skin detachment. The occurred on the seventh day therapy cefadroxil. Erosive-ulcerative occasionally crusted were apparent medial lateral canthus both eyes, ventral neck, abdomen, perivulvar region, periungual aspect front hindlimbs. Diffuse severe exfoliation present dorsum tail base in external ear canals. also dehydrated, tachycardic febrile. Histopathological examination revealed extensive epidermal ulceration, interface dermatitis vacuolar degeneration, apoptosis at multiple levels basal, suprabasal spinous dermoepidermal histopathological diagnosis consistent Stevens–Johnson syndrome/toxic necrolysis (SJS/TEN). recently reported Algorithm Drug ...