Epidemiology and costs of patients with toxic epidermal necrolysis: a 27-year retrospective study

摘要: Background Recently, the importance of reporting results and principles management in Toxic epidermal necrolysis (TEN) patients was underscored. Treatment TEN focuses on supportive care, often provided a burn centre setting. Mortality can be high; SCORTEN score is scoring system that predicts mortality with TEN. The predictive value our setting unclear, as are treatment costs patients. Objective To describe patient characteristics, treatment, outcome direct medical treated one Dutch 27-year period. In addition, determinants were assessed. Methods A retrospective study conducted all (including Stevens–Johnson syndrome (SJS) overlap SJS-TEN) admitted to Rotterdam between January 1987 December 2013. discriminative assessed by receiver-operator characteristics curve analysis. Results A total 63 Overall 39.7%, (>30%TBSA) 37.1%. A higher age (OR = 1.04, 95%CI: 1.02–1.07) comorbidity 4.25, 1.2–14.7) associated mortality. prediction model population limited (AUC=0.72, 0.57–0.86). mean hospital-based €41.361. Conclusion Toxic severe adverse drug reaction, high Elderly comorbidity, especially circulatory have relatively risk decease. score, frequently used TEN, underestimated study, mainly due availability good prognosis. costs, also compared general.