Regional Cardiac Sympathetic Nerve Dysfunction and the Diagnostic Efficacy of Metaiodobenzylguanidine Tomography in Stable Coronary Artery Disease

摘要: Abstract The present study endeavors to correlate regional myocardial sympathetic nerve dysfunction with reversible and persistent perfusion abnormalities depressed wall motion, determine the diagnostic efficacy of radio-iodinated metaiodobenzylguanidine (MIBG) tomography for detecting coronary artery disease. In 28 consecutive patients stable disease 7 atypical chest pain but no stenosis, MIBG uptake was semiquantitatively evaluated in 13 left ventricular segments early (30 minutes) late (4 hours) after injection. Regional reduced 68 90 (76%) showing abnormality 72 81 (89%) 4 hours Although sensitivity negative predictive values scanning were relatively high (82% 85%, respectively), specificity, positive value, kappa value low (63%, 57%, 0.41, respectively). Right lesions detected by a (85%) specificity (41%). Conversely, sensitivities other 2 major arteries (55%). overall accuracy 66% low; 60%, 70%, 0.31, respectively. Similarly, observed 42 49 asynergic (86%) on scans, which 32 viable 10 nonviable; (73%) (44%) (0.43). Thus, cardiac innervation is impaired ischemic, noninfarcted myocardium as well infarcted or has abnormality. detect disease, however, limited probably because nonspecific reductions inferior posterolateral regions. (Am J Cardiol 1996;78:292–297)