Helicobacter pylori inflammation, immunity, and vaccines.

摘要: Helicobacter pylori infects almost 50% of the world population and is major cause gastroduodenal diseases. H. colonizes gastric mucosa, activates Toll-like Nod-like receptors, usually elicits a T helper 1 (Th1) type immune response, fully polarized in peptic ulcer patients. Among several bacterial factors, neutrophil-activating protein represents key factor driving Th1 inflammation. A complex fascinating balance between host factors takes part niche allows majority infected individuals to be without any symptom during their entire life. Novel insights into innate adaptive responses against pylori, dealing with regulatory cells cytokines, CTLA-4 molecule, cholesterol glucosylation, evasion have been elucidated past year are discussed for development an effective vaccine.