TGFB1 gene polymorphisms: their relevance in the susceptibility to Helicobacter pylori -related diseases

摘要: Recent studies have revealed elevated expression of transforming growth factor β1 (TGF-β1) in gastric mucosa patients with cancer (GC) and those undergoing ulcer repair. As production TGF-β1 is genetically regulated, we aimed to assess whether functional polymorphisms the TGFB1 gene are involved susceptibility clinical characteristics Helicobacter pylori-related diseases. DNA from 142 unrelated Spanish GC, 200 peptic 342 healthy controls was typed for MspA1I T+869C, Sau96I G+915C using polymerase chain reaction RFLP analysis. H. pylori infection CagA/VacA antibody status were determined by Western blot controls. (odds ratio (OR): 11.44; 95% confidence interval (CI): 4.45–29.42; P<0.001) non-steroidal anti-inflammatory drugs (OR: 5.07; CI: 2.53–10.16; identified as independent risks factors duodenal (DU), whereas TGFB1+869*C/C genotype associated reduced risk developing disease 0.32; CI=0.15–0.68; P=0.003). Our results show that T+869C polymorphism DU provide further evidence host genetic play a key role pathogenesis