Association of Transforming Growth Factor-beta 1 Polymorphisms with Genetic Susceptibility to TNM Stage I or II Gastric Cancer
作者： P. Zhang , J.-Z. Di , Z.-Z. Zhu , H.-M. Wu , Y. Wang
DOI: 10.1093/JJCO/HYN111
关键词:
摘要: Transforming growth factor-beta 1 (TGF-b1) inhibits the proliferation of tumors in early stages cancers, whereas it promotes tumor and metastasis later cancers. To examine effect TGF-b1 polymorphisms on gastric cancer risk, we studied association between C2509T Tþ29C (Leu10Pro) TGF-b 1a nd risk 414 cases controls Chinese population. When overall were compared with controls, no significant difference was found genotype distributions for both examined. However, when stratified by stage, 2509T þ29C allele carriers had a 0.57-fold (95% CI ¼ 0.36 –0 .90) 0.58-fold .91) decreased TNM stage IþII cancer, respectively, as non-carriers. We conclude that TGF-b12509T alleles may have protective role development cancer.
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