Robust neuronal dynamics in premotor cortex during motor planning

摘要: Neural activity maintains representations that bridge past and future events, often over many seconds. Network models can produce persistent ramping activity, but the positive feedback is critical for these slow dynamics cause sensitivity to perturbations. Here we use electrophysiology optogenetic perturbations in mouse premotor cortex probe robustness of neural during motor planning. We show preparatory remarkably robust large-scale unilateral silencing: detailed drive specific movements were quickly selectively restored by network. Selectivity did not recover after bilateral silencing cortex. Perturbations one hemisphere are thus corrected information from other hemisphere. Corpus callosum bisections demonstrated hemispheres maintain independently. Redundancy across coupled modules, as observed cortex, a hallmark control systems. incorporating principles consistent with data.