Capacity to produce interleukin 2 is impaired in haemophilia in the absence and presence of HIV 1 infection.
作者： R. Madhok , J. A. Gracie , J. Smith , G. D. O. Lowe , C. D. Forbes
DOI: 10.1111/J.1365-2141.1990.TB07838.X
关键词:
摘要: Summary. Capacity to produce interleukin-2 (IL-2) was measured in haemophiliacs from a well-defined treated cohort. Patients were selected on the basis of HIV-1 antibody status, mean annual dose clotting factor and liver disease severity. T-cell subsets peripheral blood mononuclear cell proliferation Mycobacterium tuberculosis purified protein derivative (PPD) also measured. Haemophiliacs had reduced IL-2 production, independent concentrate used In positive patients levels correlated with PPD proliferative responses (r=0.6, P=0.04) CD8+ve (r=05, P=0.05) but not CD4 + ve numbers (r= 0.3, P=0.2). No such correlations seen negative patients. Reduced production due qualitative defect. HTV-1 defect T lymphocytes that selectively proliferate response observed. patients.
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