A brain-specific homeobox gene, Bsx, is essential for proper postnatal growth and nursing.
作者： Tara McArthur , Akihira Ohtoshi
DOI: 10.1128/MCB.00215-07
关键词:
摘要: To investigate in vivo roles of a murine hypothalamic homeobox gene, Bsx, we generated and analyzed two mutant alleles, Bsx(DeltaHD) Bsx(lacZ). lacks the homeodomain, Bsx(lacZ) is an insertion lacZ reporter gene. Bsx-lacZ expression was detected hypothalamus pineal gland reiterates Bsx expression. homozygous mice were born at expected Mendelian ratio, but their growth impaired. Offspring from females exhibited low survival rate due to nursing defect. Mammary glands developed normally during pregnancy; however, they involuted quickly after parturition. These results demonstrate that required for postnatal maintenance lactating mammary glands. Thus, mouse likely involved systemic control suppression apoptosis postpartum epithelial cells.
sci-hub.se 参考文章(45)
H. Li, P. S. Zeitler, M. T. Valerius, K. Small, S. S. Potter, Gsh-1, an orphan Hox gene, is required for normal pituitary development. The EMBO Journal. ,vol. 15, pp. 714- 724 ,(1996) , 10.1002/J.1460-2075.1996.TB00407.X
Mt Dattani, Ic Robinson, The molecular basis for developmental disorders of the pituitary gland in man. Clinical Genetics. ,vol. 57, pp. 337- 346 ,(2000) , 10.1034/J.1399-0004.2000.570503.X
Kathryn L. Schwertfeger, Monica M. Richert, Steven M. Anderson, Mammary Gland Involution Is Delayed by Activated Akt in Transgenic Mice Molecular Endocrinology. ,vol. 15, pp. 867- 881 ,(2001) , 10.1210/MEND.15.6.0663
N. D. Horseman, Defective mammopoiesis, but normal hematopoiesis, in mice with a targeted disruption of the prolactin gene The EMBO Journal. ,vol. 16, pp. 6926- 6935 ,(1997) , 10.1093/EMBOJ/16.23.6926
Jean-Yves Vollmer, Roger G. Clerc, Homeobox Genes in the Developing Mouse Brain Journal of Neurochemistry. ,vol. 71, pp. 1- 19 ,(2002) , 10.1046/J.1471-4159.1998.71010001.X
Tomonori Hosoya, Yoshihito Oda, Satoru Takahashi, Masanobu Morita, Shimako Kawauchi, Masatsugu Ema, Masayuki Yamamoto, Yoshiaki Fujii-Kuriyama, Defective development of secretory neurones in the hypothalamus of Arnt2-knockout mice Genes to Cells. ,vol. 6, pp. 361- 374 ,(2001) , 10.1046/J.1365-2443.2001.00421.X
Andrew P. Gigliotti, James W. DeWille, Local signals induce CCAAT/enhancer binding protein-δ (C/EBP-δ) and C/EBP-β mRNA expression in the involuting mouse mammary gland Breast Cancer Research and Treatment. ,vol. 58, pp. 57- 63 ,(1999) , 10.1023/A:1006381906288
R. S. Chapman, P. C. Lourenco, E. Tonner, D. J. Flint, S. Selbert, K. Takeda, S. Akira, A. R. Clarke, C. J. Watson, Suppression of epithelial apoptosis and delayed mammary gland involution in mice with a conditional knockout of Stat3 Genes & Development. ,vol. 13, pp. 2604- 2616 ,(1999) , 10.1101/GAD.13.19.2604
M. Li, X. Liu, G. Robinson, U. Bar-Peled, K.-U. Wagner, W. S. Young, L. Hennighausen, P. A. Furth, Mammary-derived signals activate programmed cell death during the first stage of mammary gland involution Proceedings of the National Academy of Sciences of the United States of America. ,vol. 94, pp. 3425- 3430 ,(1997) , 10.1073/PNAS.94.7.3425
Jacques L. Michaud, Charles DeRossi, Noah R. May, Bernadette C. Holdener, Chen-Ming Fan, ARNT2 acts as the dimerization partner of SIM1 for the development of the hypothalamus. Mechanisms of Development. ,vol. 90, pp. 253- 261 ,(2000) , 10.1016/S0925-4773(99)00328-7