Impact of acquisition time-window on clinical whole-body PET parametric imaging

摘要: Whole-body PET parametric imaging can combine the benefit of extended axial field-of-view (FOV) in multi-bed scans with that generating time activity curves (TACs) dynamic scans. We have recently proposed such a framework capable delivering whole-body FDG Patlak images clinically feasible scan times. The design acquisition protocol was limited to single time-window and standard graphical analysis method. However, relatively long half-life uptake, compared acceptable time-windows, render choice this window critical. major kinetic components be estimated from early intermediate TAC segments. On contrary, at later tumor contrast may overall higher. In addition, method does not account for tracer uptake reversibility, property becomes more apparent time-windows certain tumors, thus increasing probability larger bias Consequently, optimal critical should constitute an important aspect protocols. present work we assessed impact sliding on images. This included incremental shift 6-pass (∼35min) along period 0–90min post injection, using both real patient data as well realistic 4D simulations state-of-the-art Siemens Biograph mCT scanner. also propose selective application generalized accounting reversibility. Our simulated clinical results demonstrate methods (standard generalized) result enhanced tumor-to-background contrast-to-noise ratios minimal (10–45min injection) exhibiting systematically superior performance.