Preoperative carcinoembryonic antigen predicts outcomes in node-negative colon cancer patients: a multivariate analysis of 572 patients

摘要: Abstract Background: Although prospective trials have demonstrated that postoperative chemotherapy for nodepositive colon cancer patients provides survival benefit, no improvement in has been documented node-negative patients. There are, however, a subset of go on to die their disease. We hypothesize this may benefit from chemotherapy. analyzed large cohort nodenegative single institution determine prognostic factors predict which with might experience recurrence and can Study Design: A review the database colorectal at Memorial Sloan-Kettering Cancer Center (MSKCC) between 1985 1993 identified 572 who underwent curative resection (T 1,2,3,4 N 0 M ). Demographic, serum, pathologic were significance. Survival was calculated by method Kaplan-Meier compared log rank test. Multivariate analysis Cox proportional hazard model. Results: Median follow-up 35 months. Factors predictive univariate include tumor stage, overall preoperative serum carcinoembryonic antigen (CEA) elevation. By multivariate analysis, stage CEA level predicted survival. Conclusions: Routine histologic demographic do not outcome Preoperative analysis. elevation identifies group poor prognosis defines