Syndecan-1 enhances the endometrial cancer invasion by modulating matrix metalloproteinase-9 expression through nuclear factor κB

摘要: Abstract Objectives Up-regulated expression of syndecan-1, a member the transmembranous proteoglycans that serves as co-receptor for wide pool extracellular ligands, has been ascribed to promotion growth various cancers including breast, ovarian, and endometrial cancers. Here, we have extended these observations gain insight into correlation between level syndecan-1 its tumor-promoting characteristics, particularly, cancer invasion, in cancer. Methods Human was stably transfected three human cell lines, effects were examined with respect survival/proliferation invasion. In addition, activation underlying signaling components, integrins, focal adhesion kinase (FAK), nuclear factor κB (NF-κB) examined. The activity NF-κB transcription matrix metalloproteinase (MMP)-9 assessed. Results innate moderate high all lines. Overexpression promoted tumor proliferation concomitant NF-κB. Furthermore, overexpression markedly enhanced invasion accompanied by integrin αv/β5 phosphorylation FAK. transcriptional MMP-9 up-regulated overexpression. Conclusion These findings provide evidence supports may critical role carcinogenic progression, contributing development proliferative invasive phenotype through NF-κB-mediated gene