Role of adenosine in the gastric blood flow response to pentagastrin in the rat.

摘要: We tested the hypothesis that increase in gastric mucosal blood flow during pentagastrin-stimulated acid secretion rat is mediated partly by endogenously generated adenosine. In vivo microscopic studies, topical 10(-5) to 10(-3) M adenosine dose-dependently dilated submucosal arterioles, vessels control flow. The receptor antagonist 8-phenyltheophylline, significantly reduced adenosine's vasodilatory response. An analog with a high A2 affinity was 100 times more potent as vasodilator than one A1 but lower affinity. then examined effect of i.v. 10 mg/kg, on and secretion. Mucosal estimated hydrogen clearance technique. Pentagastrin increased from 26.6 +/- 2.6 42.7 4.9 ml/min/100 g this 31.9 3.1 upon addition 8-phenyltheophylline. Gastric stimulated pentagastrin further 8-phenyltheophylline 2.06 0.34 mEq H+ per min 2.84 0.49 mEq/min. 8-Phenyltheophylline had no basal or contrast, nonmethylxanthine phosphodiesterase inhibitor RO 20-1724 administration. data suggest arterioles contain receptors subtype vasodilate when activated.(ABSTRACT TRUNCATED AT 250 WORDS)