Membrane-Thinning Effect of Curcumin
作者： Wei-Chin Hung , Fang-Yu Chen , Chang-Chun Lee , Yen Sun , Ming-Tao Lee
DOI: 10.1529/BIOPHYSJ.107.126888
关键词:
摘要: Interaction of curcumin with lipid bilayers is not well understood. A recent experiment showed that significantly affected the single-channel lifetime gramicidin in a 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC) bilayer without affecting its conductance. We performed two experiments to understand this result. By isothermal titration calorimetry, we measured partition coefficient binding DOPC bilayers. x-ray lamellar diffraction, thickness change as function curcumin/lipid ratio. nonlinear membrane-thinning effect by was discovered. The data were qualitatively interpreted combination calorimetry and results. show only does thin bilayer, it might also weaken elasticity moduli. result implies may affect membrane proteins modifying properties host membrane.
core.ac.uk
harvard.edu
elsevier.com
rice.edu 参考文章(35)
Denise V. Greathouse, Roger E. Koeppe, Lyndon L. Providence, S. Shobana, Olaf S. Andersen, Design and characterization of gramicidin channels. Methods in Enzymology. ,vol. 294, pp. 525- 550 ,(1999) , 10.1016/S0076-6879(99)94031-4
Torsten Wieprecht, Joachim Seelig, Isothermal titration calorimetry for studying interactions between peptides and lipid membranes Current Topics in Membranes. ,vol. 52, pp. 31- 56 ,(2002) , 10.1016/S1063-5823(02)52004-4
S.B. Hladky, D.A. Haydon, Ion Movements in Gramicidin Channels Current Topics in Membranes and Transport. ,vol. 21, pp. 327- 372 ,(1984) , 10.1016/S0070-2161(08)60444-X
F. Y. Chen, W. C. Hung, Huey W. Huang, Critical Swelling of Phospholipid Bilayers Physical Review Letters. ,vol. 79, pp. 4026- 4029 ,(1997) , 10.1103/PHYSREVLETT.79.4026
Mehrdad Khajavi, Kensuke Shiga, Wojciech Wiszniewski, Feng He, Chad A. Shaw, Jiong Yan, Theodore G. Wensel, G. Jackson Snipes, James R. Lupski, Oral Curcumin Mitigates the Clinical and Neuropathologic Phenotype of the Trembler-J Mouse: A Potential Therapy for Inherited Neuropathy American Journal of Human Genetics. ,vol. 81, pp. 438- 453 ,(2007) , 10.1086/519926
A.S. Arseniev, I.L. Barsukov, V.F. Bystrov, A.L. Lomize, Yu.A. Ovchinnikov, 1H-NMR study of gramicidin A transmembrane ion channel: Head-to-head right-handed, single-stranded helices FEBS Letters. ,vol. 186, pp. 168- 174 ,(1985) , 10.1016/0014-5793(85)80702-X
P. S. Chen, T. Y. Toribara, Huber. Warner, Microdetermination of Phosphorus Analytical Chemistry. ,vol. 28, pp. 1756- 1758 ,(1956) , 10.1021/AC60119A033
Helgi I. Ingolfsson, Roger E. Koeppe, Olaf S. Andersen, Curcumin is a Modulator of Bilayer Material Properties Biochemistry. ,vol. 46, pp. 10384- 10391 ,(2007) , 10.1021/BI701013N
Torsten Wieprecht, Michael Beyermann, Joachim Seelig, Binding of antibacterial magainin peptides to electrically neutral membranes: thermodynamics and structure. Biochemistry. ,vol. 38, pp. 10377- 10387 ,(1999) , 10.1021/BI990913+
W.C. Hung, F.Y. Chen, Huey W. Huang, Order-disorder transition in bilayers of diphytanoyl phosphatidylcholine. Biochimica et Biophysica Acta. ,vol. 1467, pp. 198- 206 ,(2000) , 10.1016/S0005-2736(00)00221-2