Hemorrhagic death associated with a high titer factor V inhibitor.

摘要: An acquired bleeding diathesis was first noted in a 51-year-old patient 11 days following an exploratory laparotomy. Laboratory studies indicated the cause of to be development circulating anticoagulant which inhibited factor V activity. The inhibitor, immunoglobulin IgG class, separated by use Sephadex G-200 filtration, disc electrophoresis, and isoelectric focusing. Despite vigorous immunosuppressive, antifibrinolytic, replacement therapy, including “prothrombin complex” plasmaphoresis, could not reversed died hemorrhage. Although inhibitors are usually associated with major life-threatening hemorrhage, this case demonstrates that such inhibitor can ominous finding. aminoglycoside antibiotic other patients so reported may one contributing causes inhibitor.