Age-related differences in cross-sectional geometry of the forearm bones in healthy women

摘要: Men exhibit age-related adaptive changes in long bone geometry, namely, endosteal resorption and periosteal apposition of bone, that help to preserve strength. It is not clear whether women undergo similar responses. To address this question, we assessed the mineral density cross-sectional geometry radius ulna at one-third distal site by single photon absorptiometry computed tomography (CT) healthy young (n=21, age 20–30 years) older (n=22, 63–84 women. We used CT data compute total subperiosteal, medullary, cortical areas, as well maximum, minimum, polar moments inertia. normalized geometric parameters for length performed comparisons using both original size-corrected data. Radial ulnar content were 20–30% lower (P<0.0001). Ulnar width, area, medullary maximum moment inertia greater than younger Although observed trends when examined corrected size, differences radial less pronounced significant. conclude with age, thereby exhibiting an pattern helps The different behavior these two bones suggests local, rather systemic, factors underlie adaptation.