The balance between two isoforms of LEF-1 regulates colon carcinoma growth
作者： Shu-Hong Wang , Ke-Jun Nan , Yao-Chun Wang , Wen-Juan Wang , Tao Tian
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摘要: Background Colon cancer is one of the most aggressive human malignancies, with a very poor prognosis. Although it has been suggested that different isoforms lymphoid enhancer factor (LEF-1) have opposing biological activities, outcome aberrant LEF-1 activation in colon still unclear. The aim this study was to evaluate effect phenotypes on growth carcinoma cell lines. A deeper understanding these processes might improve targeted therapies for by regulating expression LEF-1.
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Frank J.T. Staal, Hans C. Clevers, WNT signalling and haematopoiesis: a WNT-WNT situation. Nature Reviews Immunology. ,vol. 5, pp. 21- 30 ,(2005) , 10.1038/NRI1529
Xing-Bin Hu, Fan Feng, Yao-Chun Wang, Lin Wang, Fei He, Guo-Rui Dou, Liang Liang, Hong-Wei Zhang, Ying-Min Liang, Hua Han, Blockade of Notch signaling in tumor-bearing mice may lead to tumor regression, progression, or metastasis, depending on tumor cell types. Neoplasia. ,vol. 11, pp. 32- 38 ,(2009) , 10.1593/NEO.81008
Xiaoyan Shen, Shaohai Wang, Hongbo Wang, Minglin Liang, Lan Xiao, Zehua Wang, The role of SDF-1/CXCR4 axis in ovarian cancer metastasis Journal of Huazhong University of Science and Technology [Medical Sciences]. ,vol. 29, pp. 363- 367 ,(2009) , 10.1007/S11596-009-0320-0
Shannon Otsuka, Gwyn Bebb, The CXCR4/SDF-1 Chemokine Receptor Axis: A New Target Therapeutic for Non-small Cell Lung Cancer Journal of Thoracic Oncology. ,vol. 3, pp. 1379- 1383 ,(2008) , 10.1097/JTO.0B013E31818DDA9D
Karen C. Young, Eneida Torres, Konstantinos E. Hatzistergos, Dorothy Hehre, Cleide Suguihara, Joshua M. Hare, Inhibition of the SDF-1/CXCR4 Axis Attenuates Neonatal Hypoxia-Induced Pulmonary Hypertension Circulation Research. ,vol. 104, pp. 1293- 1301 ,(2009) , 10.1161/CIRCRESAHA.109.197533
Karine Hovanes, Tony W.H. Li, Jesus E. Munguia, Trung Truong, Tatjana Milovanovic, J. Lawrence Marsh, Randall F. Holcombe, Marian L. Waterman, Beta-catenin-sensitive isoforms of lymphoid enhancer factor-1 are selectively expressed in colon cancer. Nature Genetics. ,vol. 28, pp. 53- 57 ,(2001) , 10.1038/NG0501-53
Tong-Chuan He, Andrew B Sparks, Carlo Rago, Heiko Hermeking, Leigh Zawel, Luis T Da Costa, Patrice J Morin, Bert Vogelstein, Kenneth W Kinzler, None, Identification of c-MYC as a Target of the APC Pathway Science. ,vol. 281, pp. 1509- 1512 ,(1998) , 10.1126/SCIENCE.281.5382.1509
Chris J. Scotton, Rachel C. Chambers, Molecular Targets in Pulmonary Fibrosis: The Myofibroblast in Focus Chest. ,vol. 132, pp. 1311- 1321 ,(2007) , 10.1378/CHEST.06-2568
Z. Liu, J. F. Habener, Stromal cell-derived factor-1 promotes survival of pancreatic beta cells by the stabilisation of beta-catenin and activation of transcription factor 7-like 2 (TCF7L2) Diabetologia. ,vol. 52, pp. 1589- 1598 ,(2009) , 10.1007/S00125-009-1384-X
Jürgen Floege, Bart Smeets, Marcus J. Moeller, The SDF-1/CXCR4 Axis Is a Novel Driver of Vascular Development of the Glomerulus Journal of The American Society of Nephrology. ,vol. 20, pp. 1659- 1661 ,(2009) , 10.1681/ASN.2009060621