Identification of c-MYC as a Target of the APC Pathway

作者: Tong-Chuan He , Andrew B Sparks , Carlo Rago , Heiko Hermeking , Leigh Zawel

DOI: 10.1126/SCIENCE.281.5382.1509

关键词:

摘要: … MYC oncogene is identified as a target gene in this signaling pathway. Expression of c-MYC … Tcf-4 binding sites in the c-MYC promoter. These results provide a molecular framework for …

参考文章(31)
Jin Jen, J Wade Harper, Sandra H Bigner, Darell D Bigner, Nickolas Papadopoulos, Sanford Markowitz, James KV Willson, Kenneth W Kinzler, Bert Vogelstein, None, Deletion of p16 and p15 Genes in Brain Tumors Cancer Research. ,vol. 54, pp. 6353- 6358 ,(1994)
Bert Vogelstein, Kenneth W. Kinzler, Thomas D. Pollard, Kelly J. Smith, Pamela Maupin, Daniel B. Levy, Wild-Type but not Mutant APC Associates with the Microtubule Cytoskeleton Cancer Research. ,vol. 54, pp. 3672- 3675 ,(1994)
Gregory J. Kato, Chi V. Dang, Function of the c-Myc oncoprotein The FASEB Journal. ,vol. 6, pp. 3065- 3072 ,(1992) , 10.1096/FASEBJ.6.12.1521738
W R Sellers, W G Kaelin, Role of the retinoblastoma protein in the pathogenesis of human cancer. Journal of Clinical Oncology. ,vol. 15, pp. 3301- 3312 ,(1997) , 10.1200/JCO.1997.15.11.3301
M. van de Wetering, M. Oosterwegel, D. Dooijes, H. Clevers, Identification and cloning of TCF-1, a T lymphocyte-specific transcription factor containing a sequence-specific HMG box. The EMBO Journal. ,vol. 10, pp. 123- 132 ,(1991) , 10.1002/J.1460-2075.1991.TB07928.X
P. J. Morin, B. Vogelstein, K. W. Kinzler, APOPTOSIS AND APC IN COLORECTAL TUMORIGENESIS Proceedings of the National Academy of Sciences of the United States of America. ,vol. 93, pp. 7950- 7954 ,(1996) , 10.1073/PNAS.93.15.7950
Joanna Groden, Andrew Thliveris, Wade Samowitz, Mary Carlson, Lawrence Gelbert, Hans Albertsen, Geoff Joslyn, Jeff Stevens, Lisa Spirio, Margaret Robertson, Leslie Sargeant, Karen Krapcho, Erika Wolff, Randall Burt, J.P. Hughes, Janet Warrington, John McPherson, John Wasmuth, Denis Le Paslier, Hadi Abderrahim, Daniel Cohen, Mark Leppert, Ray White, Identification and characterization of the familial adenomatous polyposis coli gene Cell. ,vol. 66, pp. 589- 600 ,(1991) , 10.1016/0092-8674(81)90021-0
R. Day, B. Johnson, M. Skolnick, A Kamb, N. Gruis, J Weaver-Feldhaus, Q Liu, K Harshman, S. Tavtigian, E Stockert, A cell cycle regulator potentially involved in genesis of many tumor types Science. ,vol. 264, pp. 436- 440 ,(1994) , 10.1126/SCIENCE.8153634
C. Rodriguez-Alfageme, E. J. Stanbridge, S. M. Astrin, Suppression of deregulated c-MYC expression in human colon carcinoma cells by chromosome 5 transfer Proceedings of the National Academy of Sciences of the United States of America. ,vol. 89, pp. 1482- 1486 ,(1992) , 10.1073/PNAS.89.4.1482
Moritaka Ohhara, Mariko Esumi, Yasuhiko Kurosu, Activation but Not Inactivation of theMTS1Gene Is Associated with Primary Colorectal Carcinomas Biochemical and Biophysical Research Communications. ,vol. 226, pp. 791- 795 ,(1996) , 10.1006/BBRC.1996.1430