Frequent loss of TIMP-3 expression in progression of esophageal and gastric adenocarcinomas.
作者： Ping Gu , Xiangbin Xing , Marc Tänzer , Christoph Röcken , Wilko Weichert
DOI: 10.1593/NEO.08208
关键词:
摘要: Abstract Tissue inhibitor of metalloproteinase 3 ( TIMP-3 ) promoter methylation has been linked to loss expression in various cancers. In this study, we analyzed gene using MethyLight assay and mRNA reverse transcription–polymerase chain reaction analysis 22 esophageal cancers, 27 gastric carcinomas, 7 cancer cell lines. We also protein by immunohistochemistry its association with clinicopathological characteristics two cohorts comprising a total 347 patients. The was more commonly methylated adenocarcinomas the esophagus (9/13) stomach (9/15) than corresponding nonneoplastic mucosa (1/8; P = .024) (2/14; .021). patients, decreased diffuse-type cancers poor differentiation associated survival .04). summary, observed frequent seems be clinical prognostic relevance these
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