Immunohistochemical analysis of TIMP-3 and MMP-9 in actinic keratosis, squamous cell carcinoma of the skin, and basal cell carcinoma
作者： Fabiano O Poswar , Carlos AC Fraga , Lucyana C Farias , John D Feltenberger , Vitória PD Cruz
DOI: 10.1016/J.PRP.2013.08.002
关键词: Staining 、 Squamous cell carcinoma of the skin 、 Cancer 、 Pathology 、 Actinic keratosis 、 Basal cell carcinoma 、 Matrix metalloproteinase 、 Parenchyma 、 Biology 、 Immunohistochemistry
摘要: The expression of metalloproteinases and their inhibitors has been related to different invasive metastatic potentials in cancer. This study aims investigate the immunohistochemical TIMP-3 MMP-9 samples basal cell carcinoma (BCC), squamous skin (SCC), actinic keratosis (AK). Immunohistochemistry was performed evaluate BCC (n=22), SCC (n=10), AK (n=15). Ten fields both tumor parenchyma stroma were photographed counted image software. ratio positive cells total used quantify staining. A higher found compared AK. No significant differences observed among groups. Considering well-described between these neoplasms, results provide additional evidence role invasiveness keratinocyte-derived tumors.
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