Genome-wide transcriptional profiling in human squamous cell carcinoma of the skin identifies unique tumor-associated signatures.
作者： Vinnie P. KATHPALIA , Erich N. MUSSAK , Selwyn S. CHOW , Phillip H. LAM , Nathan SKELLEY
DOI: 10.1111/J.1346-8138.2006.00075.X
关键词:
摘要: The elucidation of specific genetic changes associated with human cancer pathogenesis has focused efforts to relate such the neoplastic phenotype. To further our understanding basis squamous cell carcinoma (SCC) skin, this study used a genome-wide (12 627 sequences) approach determine transcriptional signatures in lesional and nonlesional sites from five SCC patients. Several novel genes involving p53 pathway, anti-apoptotic pathways, signal transduction, structural loss DNA replication, including BCL2A1, MUC4, PTPN11 (SHP2) FGF9, are upregulated could warrant regarding their role disease pathogenesis. pathology is likely combinatorial nature compounded several cellular processes.
sci-hub.se 参考文章(38)
Tomoki Todo, Tatsuya Kondo, Takaaki Kirino, Akio Asai, Eric F. Adams, Satoshi Nakamura, Kazuhiko Ikeda, Tsutomu Kurokawa, Expression and growth stimulatory effect of fibroblast growth factor 9 in human brain tumors. Neurosurgery. ,vol. 43, pp. 337- 346 ,(1998) , 10.1097/00006123-199808000-00098
Paolo Sassone-Corsi, Craig A Mizzen, Peter Cheung, Claudia Crosio, Lucia Monaco, Sylvie Jacquot, André Hanauer, C David Allis, Requirement of Rsk-2 for epidermal growth factor-activated phosphorylation of histone H3. Science. ,vol. 285, pp. 886- 891 ,(1999) , 10.1126/SCIENCE.285.5429.886
Leo S. Price, Amra Hajdo-Milasinovic, Jun Zhao, Fried J. T. Zwartkruis, John G. Collard, Johannes L. Bos, Rap1 Regulates E-cadherin-mediated Cell-Cell Adhesion Journal of Biological Chemistry. ,vol. 279, pp. 35127- 35132 ,(2004) , 10.1074/JBC.M404917200
Todd W Ridky, Paul A. Khavari, Pathways sufficient to induce epidermal carcinogenesis. Cell Cycle. ,vol. 3, pp. 621- 624 ,(2004) , 10.4161/CC.3.5.860
Muthusamy Thangaraju, Shikha Sharan, Esta Sterneck, Comparison of mammary gland involution between 129S1 and C57BL/6 inbred mouse strains: differential regulation of Bcl2a1, Trp53, Cebpb, and Cebpd expression Oncogene. ,vol. 23, pp. 2548- 2553 ,(2004) , 10.1038/SJ.ONC.1207363
Y. Urade, J. Oberdick, R. Molinar-Rode, J. I. Morgan, Precerebellin is a cerebellum-specific protein with similarity to the globular domain of complement C1q B chain Proceedings of the National Academy of Sciences of the United States of America. ,vol. 88, pp. 1069- 1073 ,(1991) , 10.1073/PNAS.88.3.1069
Mitchell F. Denning, Yihua Wang, Brian J. Nickoloff, Tamara Wrone-Smith, Protein Kinase Cδ Is Activated by Caspase-dependent Proteolysis during Ultraviolet Radiation-induced Apoptosis of Human Keratinocytes Journal of Biological Chemistry. ,vol. 273, pp. 29995- 30002 ,(1998) , 10.1074/JBC.273.45.29995
N.U AHMED, M. UEDA, M. ICHIHASHI, Increased level of c-erbB-2/neu/HER-2 protein in cutaneous squamous cell carcinoma British Journal of Dermatology. ,vol. 136, pp. 908- 912 ,(1997) , 10.1046/J.1365-2133.1997.01806.X
Chengliu Jin, Fen Wang, Xiaochong Wu, Chundong Yu, Yongde Luo, Wallace L. McKeehan, Directionally Specific Paracrine Communication Mediated by Epithelial FGF9 to Stromal FGFR3 in Two-Compartment Premalignant Prostate Tumors Cancer Research. ,vol. 64, pp. 4555- 4562 ,(2004) , 10.1158/0008-5472.CAN-03-3752
Masanobu Komatsu, Scott Jepson, Maria E Arango, Coralie A Carothers Carraway, Kermit L Carraway, Muc4/sialomucin complex, an intramembrane modulator of ErbB2/HER2/Neu, potentiates primary tumor growth and suppresses apoptosis in a xenotransplanted tumor. Oncogene. ,vol. 20, pp. 461- 470 ,(2001) , 10.1038/SJ.ONC.1204106