The scale-up of plant cell culture: Engineering considerations

摘要: The enormous versatility of plants has continued to provide the impetus for development plant tissue culture as a commercial production strategy secondary metabolites. Unfortunately problems with slow growth rates and low products yields, which are generally non-growth associated intracellular, have made cell culture-based processes, few exceptions, economically unrealistic. Recent developments in reactor design control, elicitor technology, molecular biology, consumer demand natural products, fuelling renaissance strategy. In this review we address engineering consequences unique characteristics cells on scale-up culture.