Diagnostic Biomarkers for Posttraumatic Stress Disorder: Promising Horizons from Translational Neuroscience Research.

摘要: Posttraumatic stress disorder (PTSD) is a heterogeneous that affects individuals exposed to trauma (e.g., combat, interpersonal violence, and natural disasters). Although its diagnostic features have been recently reclassified with the emergence of Diagnostic Statistical Manual for Mental Disorders, Fifth Edition, remains characterized by hyperarousal, intrusive reminders trauma, avoidance trauma-related cues, negative cognition mood. This heterogeneity indicates presence multiple neurobiological mechanisms underlying etiology maintenance PTSD. Translational research spanning past few decades has revealed several potential avenues identification biomarkers These include, but are not limited to, monoaminergic transmitter systems, hypothalamic-pituitary-adrenal axis, metabolic hormonal pathways, inflammatory mechanisms, psychophysiological reactivity, neural circuits. The current review provides an update literature regard most promising putative PTSD biomarkers, specific emphasis on interaction between influences disease risk symptom progression. Such will likely be identified multi-dimensional models derived from comprehensive descriptions molecular, neurobiological, behavioral, clinical phenotypes.