Expression of the human Achaete-scute 1 gene in olfactory neuroblastoma (esthesioneuroblastoma).
作者： Mark E. Carney , Robert C. O'Reilly , Bijan Sholevar , Olesia I. Buiakova , Louis D. Lowry
DOI: 10.1007/BF01054767
关键词:
摘要: Olfactory neuroblastoma (ONB) is a rare neuronal malignancy of the olfactory mucosal. Markers used in diagnosis ONB do not distinguish from other tumors or with neuroendocrine features thus making difficult. Using modified RT-PCR technique, we show that human homologue theDrosophila achaete-scute geneHASH1 expressed 6 primary and one metastatic specimens, whereas Marker Protein (OMP) not. Previous studies have shown thatHASH1 immature neurons required for their development.OMP, whose function unknown, exclusively mature neurons. Together, these data suggest derived neuroectodermal origin. Analysis RNA expression tumor specimens an established cell line make this ideal system to study growth differentiation. Furthermore, represent first molecular genetic analysis unusual tumor.
springer.com
sci-hub.se 参考文章(25)
Anne L. Calof, Murali D. Adusumalli, Melinda K. DeHamer, Jose L. Guevara, Jeff S. Mumm, Sara J. Whitehead, Arthur D. Lander, Generation, Differentiation, and Maturation of Olfactory Receptor Neurons In Vitro Springer, Tokyo. pp. 36- 40 ,(1994) , 10.1007/978-4-431-68355-1_15
Henry A. Erlich, PCR Technology: Principles and Applications for DNA Amplification ,(1989)
P I Patel, P E Framson, C T Caskey, A C Chinault, Fine structure of the human hypoxanthine phosphoribosyltransferase gene Molecular and Cellular Biology. ,vol. 6, pp. 393- 403 ,(1986) , 10.1128/MCB.6.2.393
F. L. Margolis, M. Grillo, Use of reverse transcriptase polymerase chain reaction to monitor expression of intronless genes. BioTechniques. ,vol. 9, pp. 262- 268 ,(1990)
Jerome B. Taxy, N K Bharani, Stacey E. Mills, Henry F. Frierson, Victor E. Gould, The spectrum of olfactory neural tumors. A light-microscopic immunohistochemical and ultrastructural analysis The American Journal of Surgical Pathology. ,vol. 10, pp. 687- 695 ,(1986) , 10.1097/00000478-198610000-00004
John Q. Trojanowski, Virginia Lee, Nan Pillsbury, Suzette Lee, Neuronal Origin of Human Esthesioneuroblastoma Demonstrated with Anti-Neurofilament Monoclonal Antibodies New England Journal of Medicine. ,vol. 307, pp. 159- 161 ,(1982) , 10.1056/NEJM198207153070305
J. Verhaagen, A. B. Oestreicher, M. Grillo, Y.-S. Khew-Goodall, W. H. Gispen, F. L. Margolis, Neuroplasticity in the olfactory system : Differential effects of central and peripheral lesions of the primary olfactory pathway on the expression of B 50/GAP43 and the olfactory marker protein Journal of Neuroscience Research. ,vol. 26, pp. 31- 44 ,(1990) , 10.1002/JNR.490260105
Jonathan L. Schmidt, Richard J. Zarbo, Jack L. Clark, Olfactory neuroblastoma: clinicopathologic and immunohistochemical characterization of four representative cases. Laryngoscope. ,vol. 100, pp. 1052- 1058 ,(1990) , 10.1288/00005537-199010000-00005
J L Rothstein, D Johnson, J A DeLoia, J Skowronski, D Solter, B Knowles, Gene expression during preimplantation mouse development. Genes & Development. ,vol. 6, pp. 1190- 1201 ,(1992) , 10.1101/GAD.6.7.1190
F.v. Weizsäcker, S. Labeit, H.K. Koch, W. Oehlert, W. Gerok, H.E. Blum, A simple and rapid method for the detection of RNA in formalin-fixed, paraffin-embedded tissues by PCR amplification Biochemical and Biophysical Research Communications. ,vol. 174, pp. 176- 180 ,(1991) , 10.1016/0006-291X(91)90502-X