Osteoporosis and Pathological Fractures Following Treatment with Acth and Cortisone

摘要: The profound alterations in tissue electrolytes which may occur during ACTH and cortisone therapy have been the subject of numerous reports (1-3). For most part, these emphasized disturbances sodium potassium metabolism. effects on calcium, phosphorus, alkaline phosphatase corticosteroid administration received less attention. Definite retardation chondrogenesis osteogenesis has observed rats given (4), Blunt et al (5) described poor healing fractures experimental animal receiving cortisone. In man, an increased urinary fecal excretion calcium as well a fall serum concentrations substances, noted treatment with hormones (1, 6).