Nonhomogeneous distribution of 5-hydroxyindoleacetic acid and homovanillic acid in the lumbar cerebrospinal fluid of man

摘要: The volume of the lumbar sac measured in 4 subjects was found to be 15.5 ml. Exactly 15 ml cerebrospinal fluid (L-CSF) permitted flow freely out during a puncture 20 neurological patients and small samples L-CSF were collected beginning (sample 1), at middle 2), end 3) this procedure either for 5-HIAA or HVA measurement. concentrations increased an exponential manner from sample 1 3. These results indicate that CSF is not homogeneous as generally believed certain rules have followed sampling obtain reproducible biochemical data.