Effect of intravenously administered probenecid in humans on the levels of 5-hydroxyindoleacetic acid, homovanillic acid and 3-methoxy-4-hydroxy-phenylglycol in cerebrospinal fluid.
作者： J. Korf , H.M. Van Praao , J.B. Sebens
DOI: 10.1016/0006-2952(71)90152-3
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摘要: Abstract After isolation and separation on columns of Sephadex G10, 5-hydroxyindole-acetic acid, homovanillic acid 3-methoxy-4-hydroxyphenylglycol from human lumbar cerebrospinal fluid was measured fluorimetrically. Details about fluorimetry the glycol are given. The effect intravenously administered probenecid levels three compounds in CSF investigated as a function time. acids, 5-hydroxyindoleacetic accumulated not earlier than 6 hr after administration drug. noradrenaline metabolite, 3-methoxy-4-hydroxy-phenylglycol, did accumulate under influence probenecid. lag phase 4 before accumulation acids occurs, might reflect transport time along spinal cord cisteraal- to region.
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