The Significance of the Cerebral Dopamine Metabolism in the Pathogenesis and Treatment of Psychotic Disorders
作者： H. M. van Praag
DOI: 10.1007/978-1-4684-0778-5_1
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摘要: For many years, well into the Sixties, research biological determinants of schizophrenic psychoses has suffered from a dearth more or less well-founded and testable working hypotheses. Without much system, efforts were made to find abnormal metabolites in wide variety body fluids. Strange people, strange substances: not very powerful strategy. It recently dawned, however, that neuroleptics could serve as pacemaker psychosis (Matthysse 1973; Snyder, 1974; van Praag 1975), antidepressants are depression (Van 1976a). I shall briefly discuss arguments which have led this conclusion.
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sci-hub.st 参考文章(53)
A. Barbeau, Role of dopamine in the nervous system. Monographs in human genetics. ,vol. 6, pp. 114- 136 ,(1972) , 10.1159/000392670
Current developments in psychopharmacology Spectrum , distributed by Halsted Press. ,(1981) , 10.1007/978-94-011-8123-5
Edward F. Domino, Amphetamines and related compounds Electroencephalography and Clinical Neurophysiology. ,vol. 30, pp. 579- ,(1971) , 10.1016/0013-4694(71)90160-X
H.M. van Praag, L.C.W. Dols, T. Schut, Biochemical versus psychopathological action profile of neuroleptics: A comparative study of chlorpromazine and oxypertine in acute psychotic disorders Comprehensive Psychiatry. ,vol. 16, pp. 255- 263 ,(1975) , 10.1016/0010-440X(75)90052-8
S. H. Snyder, S. P. Banerjee, H. I. Yamamura, D. Greenberg, Drugs, neurotransmitters, and schizophrenia. Science. ,vol. 184, pp. 1243- 1253 ,(1974) , 10.1126/SCIENCE.184.4143.1243
Malcolm B. Bowers, 5-Hydroxyindoleacetic acid (5 HIAA) and homovanillic acid (HVA) following probenecid in acute psychotic patients treated with phenothiazines Psychopharmacology. ,vol. 28, pp. 309- 318 ,(1973) , 10.1007/BF00422751
H.M. van Praag, The position of biological psychiatry among the psychiatric disciplines Comprehensive Psychiatry. ,vol. 12, pp. 1- 7 ,(1971) , 10.1016/0010-440X(71)90050-2
Herman M. van Praag, Cerebral Monoamines and Depression Archives of General Psychiatry. ,vol. 28, pp. 827- 831 ,(1973) , 10.1001/ARCHPSYC.1973.01750360053007
J. Korf, H.M. Van Praao, J.B. Sebens, Effect of intravenously administered probenecid in humans on the levels of 5-hydroxyindoleacetic acid, homovanillic acid and 3-methoxy-4-hydroxy-phenylglycol in cerebrospinal fluid. Biochemical Pharmacology. ,vol. 20, pp. 659- 668 ,(1971) , 10.1016/0006-2952(71)90152-3
Ben H.C. Westerink, Jakob Korf, Determination of nanogram amounts of homovanillic acid in the central nervous system with a rapid semiautomated fluorometric method Biochemical Medicine. ,vol. 12, pp. 106- 115 ,(1975) , 10.1016/0006-2944(75)90101-5