Improved preservation of larynx with the addition of cetuximab to radiation for cancers of the larynx and hypopharynx

摘要: 5533 Background: Recently a large phase III randomized trial compared the non-surgical treatments of radiation (R) with or without weekly cetuximab (C) for patients locoregionally advanced head and neck cancers oropharynx, hypopharynx larynx. Patients who received combination treatment (R+C) demonstrated statistically significant advantage respect to locoregional control survival treated alone (ASCO Abstract #5507, 2004). A subgroup analysis hypopharyngeal laryngeal carcinoma was undertaken assess rates organ preservation two treatments. Methods: Rates larynx (LP) were estimated by Kaplan-Meier method. underwent no lesser surgeries censored at death date last contact. Hazard ratio calculated Cox regression. Results: The overall included 424 171 had (R=78, R+C=93). characteristic...