Pernicious plans revealed: Plasmodium falciparum genome wide expression analysis.

作者: Manuel Llinás , Joseph L DeRisi

DOI: 10.1016/J.MIB.2004.06.014

关键词:

摘要: The asexual intraerythrocytic developmental cycle (IDC) of Plasmodium falciparum is responsible for the majority clinical manifestations malaria in humans. Although has been studied over a century, elucidation full genome sequence P. now allowed in-depth studies gene expression throughout entire stage. As mainstays anti-malarial chemotherapy become increasingly ineffective, we need deeper understanding fundamental plasmodial bioregulatory mechanisms to successfully subvert them. Recent have begun examine different aspects IDC and are providing key insights into basic regulation helping define functions. However, date, no transcription factor fully characterized from definitive identification cis-acting regulatory elements along with their corresponding trans-acting partners still lacking. characterization transcriptome first major step towards wide this parasite. data almost every can be publicly queried at and. results these suggest promising leads identifying novel targets therapeutics vaccines addition solid foundation ongoing expression.

参考文章(41)
Till S. Voss, Mirjam Kaestli, Denise Vogel, Selina Bopp, Hans-Peter Beck, Identification of nuclear proteins that interact differentially with Plasmodium falciparum var gene promoters Molecular Microbiology. ,vol. 48, pp. 1593- 1607 ,(2003) , 10.1046/J.1365-2958.2003.03528.X
Stephen L. Hoffman, William H. Bancroft, Gottlieb Michael, Stephanie L. James, Enriqueta C. Bond Burroughs, John R. Stephenson, Michael J. Morgan, Funding for malaria genome sequencing Nature. ,vol. 387, pp. 647- 647 ,(1997) , 10.1038/42571
S. Bowman, D. Lawson, D. Basham, D Brown, T. Chillingworth, C. M. Churcher, A. Craig, R. M. Davies, K. Devlin, T. Feltwell, S. Gentles, R. Gwilliam, N. Hamlin, D. Harris, S. Holroyd, T. Hornsby, P. Horrocks, K. Jagels, B. Jassal, S. Kyes, J. McLean, S. Moule, K. Mungall, L. Murphy, K. Oliver, M. A. Quail, M.-A. Rajandream, S. Rutter, J. Skelton, R. Squares, S. Squares, J. E. Sulston, S. Whitehead, J. R. Woodward, C. Newbold, B. G. Barrell, The complete nucleotide sequence of chromosome 3 of Plasmodium falciparum Nature. ,vol. 400, pp. 532- 538 ,(1999) , 10.1038/22964
Anusha Munasinghe Gunasekera, Swati Patankar, Jonathan Schug, Geoffrey Eisen, Dyann F. Wirth, Drug-induced alterations in gene expression of the asexual blood forms of Plasmodium falciparum Molecular Microbiology. ,vol. 50, pp. 1229- 1239 ,(2003) , 10.1046/J.1365-2958.2003.03787.X
Philip T. Labo, Arthur J. Milgram, Christian J. Stoeckert, David S. Roos, Patricia L. Whetzel, Shailesh V. Date, Kobby Essien, Martin J. Fraunholz, Bindu Gajria, Gregory R. Grant, John Iodice, Jessica C. Kissinger, PlasmoDB: The Plasmodium Genome Resource American Society of Microbiology. pp. 12- 23 ,(2005) , 10.1128/9781555817558.CH2
Swati Patankar, Anusha Munasinghe, Azadeh Shoaibi, Leda M. Cummings, Dyann F. Wirth, Serial analysis of gene expression in Plasmodium falciparum reveals the global expression profile of erythrocytic stages and the presence of anti-sense transcripts in the malarial parasite. Molecular Biology of the Cell. ,vol. 12, pp. 3114- 3125 ,(2001) , 10.1091/MBC.12.10.3114
(Iain) R.J.M. Wilson, Paul W. Denny, Peter R. Preiser, Kaveri Rangachari, Kate Roberts, Anjana Roy, Andrea Whyte, Malcolm Strath, Daphne J. Moore, Peter W. Moore, Donald H. Williamson, Complete gene map of the plastid-like DNA of the malaria parasite Plasmodium falciparum. Journal of Molecular Biology. ,vol. 261, pp. 155- 172 ,(1996) , 10.1006/JMBI.1996.0449
Jun Fang, Thomas F. McCutchan, Thermoregulation in a parasite's life cycle. Nature. ,vol. 418, pp. 742- 742 ,(2002) , 10.1038/418742A
Harald Noedl, Chansuda Wongsrichanalai, Robert Scott Miller, Khin Saw Aye Myint, Sornchai Looareesuwan, Yaowalark Sukthana, Varee Wongchotigul, Herwig Kollaritsch, Gerhard Wiedermann, Walther H. Wernsdorfer, Plasmodium falciparum: effect of anti-malarial drugs on the production and secretion characteristics of histidine-rich protein II Experimental Parasitology. ,vol. 102, pp. 157- 163 ,(2002) , 10.1016/S0014-4894(03)00051-1