作者: Manuel Llinás , Joseph L DeRisi
DOI: 10.1016/J.MIB.2004.06.014
关键词:
摘要: The asexual intraerythrocytic developmental cycle (IDC) of Plasmodium falciparum is responsible for the majority clinical manifestations malaria in humans. Although has been studied over a century, elucidation full genome sequence P. now allowed in-depth studies gene expression throughout entire stage. As mainstays anti-malarial chemotherapy become increasingly ineffective, we need deeper understanding fundamental plasmodial bioregulatory mechanisms to successfully subvert them. Recent have begun examine different aspects IDC and are providing key insights into basic regulation helping define functions. However, date, no transcription factor fully characterized from definitive identification cis-acting regulatory elements along with their corresponding trans-acting partners still lacking. characterization transcriptome first major step towards wide this parasite. data almost every can be publicly queried at and. results these suggest promising leads identifying novel targets therapeutics vaccines addition solid foundation ongoing expression.