Targets for modulation of fatty acid oxidation in the heart.

摘要: Fatty acids are a major source of fuel used by the heart to provide large amounts energy necessary sustain contractile function. In healthy heart, balance between fatty acid and carbohydrate use ensures that supply matches demand. However, myocardial ischemia causes profound changes in metabolism, including alterations glucose metabolism can lead excessive oxidation, which occurs at expense oxidation. This contributes cellular acidosis, decrease cardiac efficiency dysfunction ischemic heart. Inhibition oxidation has recently emerged as promising approach prevention these adverse effects acids. As result, number key enzymes involved potential targets for therapeutic intervention ischemia. includes inhibition uptake into myocyte, mitochondrial direct beta-oxidation. review describes modulation