Materials and methods for diagnosing and predicting the course of prostate cancer

摘要: Expression of Forkhead-box protein Al (FOXAl), a transcription factor important for the normal development prostate gland is thought to be controlled by steroid hormones and GATA-3. FOXAl, GATA-3 androgen receptor (AR) was retrospectively analyzed immunohistochemistry (IHC) in series 80 primary tumors 28 metastatic cancers including 15 matched paired samples. High nuclear FOXAl expression seen 19% 89% (p<0.0001). correlated positively with tumor size, extra-prostatic extension, angiolymphatic invasion, AR metastasis but did not correlate age, stage, Gleason score, presence PIN or multifocality, seminal vesicle perineural invasion status surgical excision margins. either epithelium tumor. associated cancer. Accordingly, can used classify patients at higher risk metastases.