Synthetic Peptide‐Based Receptors

摘要: Synthetic receptors that are solely or at least partly constructed from peptide segments can be regarded as conceptual links between supramolecular chemistry and biochemistry. Many of these therefore share properties characteristic both fields. They easily modified by using rational design combinatorial methods, for example. In addition, binding sensitively dependent on receptor conformation, which is in turn controlled the sequence (amino acid) subunits. this chapter, successful work area synthetic peptide-derived presented to illustrate general principles achieved. To end, divided into four types: cyclic peptides pseudopeptides, conformationally constrained containing rigid nonnatural subunits, linear with natural and/or conjugates abiotic peptide-based The examples demonstrate not only excellent mimics ligands but some cases they also possess outstanding when compared other types studied chemistry. Keywords: synthetic receptors; molecular recognition; amino acids; peptides; cyclopeptides