Essential oils from two Allium species exert effects on cell proliferation and neuroblast differentiation in the mouse dentate gyrus by modulating brain-derived neurotrophic factor and acetylcholinesterase

摘要: In the present study, we investigated effects of oil products from two Allium species: sativum (garlic) and hookeri (Chinese chives) on cell proliferation neuroblast differentiation in mouse dentate gyrus. Using corn as a vehicle, essential garlic (10 ml/kg), or Chinese chives (10 ml/kg) was administered orally to 9-week-old mice once day for 3 weeks. One hour following last treatment, novel object recognition test conducted animals were killed 2 h after test. comparison vehicle-treated group, (GO) treatment resulted significantly increased exploration time discrimination index during test, while (CO) reduced same addition, number Ki67-immunoreactive proliferating cells doublecortin-immunoreactive neuroblasts gyrus GO-treated animals. However, administration CO decreased differentiation. Administration GO brain-derived neurotrophic factor (BDNF) levels acetylcholinesterase (AChE) activity hippocampal homogenates. contrast, BDNF protein had no significant effect AChE activity, compared that group. These results suggest improves well increases differentiation, by modulating impairs decreases reducing hippocampus.