Classification of kinase inhibitors using nonlinear optical techniques
作者： Joshua S. Salafsky , Ryan McGuinness
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摘要: A method is disclosed for classifying and distinguishing between type I II kinase inhibitors. The involves the use of non-linear optical techniques, in particular second-harmonic generation (SHG) to identify conformational changes proteins obtained from known or further deducing manner binding unknown inhibitors by comparison with signal produced ligands. also applied comparing induced generic branded inhibitor drugs a target kinase.
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