The Conformational Plasticity of Protein Kinases
作者： Morgan Huse , John Kuriyan
DOI: 10.1016/S0092-8674(02)00741-9
关键词: Protein structure 、 Protein kinase domain 、 Proto-Oncogene Proteins c-abl 、 SH3 domain 、 Kinase 、 HAMP domain 、 G protein-coupled receptor kinase 、 Cell biology 、 c-Raf 、 Biology
摘要: Protein kinases operate in a large number of distinct signaling pathways, where the tight regulation their catalytic activity is crucial to development and maintenance eukaryotic organisms. The domains different adopt strikingly similar structures when they are active. By contrast, crystal inactive have revealed remarkable plasticity kinase domain that allows adoption conformations response interactions with specific regulatory or proteins.
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