Principles of Kinase Regulation

摘要: Publisher Summary Protein kinases represent one of the largest protein families, corresponding to 2 percent eukaryotic proteins. Their importance is further reflected in fact that phosphorylation most abundant type cellular regulation, affecting essentially every process, including metabolism, growth, differentiation, motility, membrane transport, learning, and memory. kinase can be regulated diverse ways, ranging from transcriptional control through subcellular localization recruitment substrates, structural chemical modifications proteins themselves. The specificity cell determined by a combination “peptide specificity” kinase, substrate recruitment, phosphatase activity. This chapter focuses on principles regulation activity at level. Allosteric widespread mechanism function; effectors bind regulatory sites distinct active site, usually inducing conformational changes influence generally bear no resemblance their target protein's substrate. Intrasteric extends enzyme classes beyond enzymes receptors targeting domains, acts intrasteric autoregulatory sequences (IARseq) resemble specific substrates or ligands varying extents. interactions typically result inhibition function, mechanisms used for activation, activators ligands, phosphorylation, proteolysis, reduction disulfide bonds, combinations these.