Crystal structure of the complex of the cyclin D-dependent kinase Cdk6 bound to the cell-cycle inhibitor p19INK4d.

摘要: The crystal structure of the cyclin D-dependent kinase Cdk6 bound to p19INK4d protein has been determined at 1.9 A resolution. results provide first structural information for a and show how INK4 family CDK inhibitors bind. indicates that conformational changes induced by inhibit both productive binding ATP cyclin-induced rearrangement from an inactive active conformation. also shows inhibitor would prevent p27Kip1, resulting in its redistribution other CDKs. Identification critical residues involved interaction explains mutations Cdk4 p16INK4a result loss inhibition cancer.