Mechanism of CDK activation revealed by the structure of a cyclinA-CDK2 complex
作者： Philip D. Jeffrey , Alicia A. Russo , Kornelia Polyak , Emma Gibbs , Jerard Hurwitz
DOI: 10.1038/376313A0
关键词: Active site 、 Chemistry 、 CDK-activating kinase 、 Allosteric regulation 、 Protein structure 、 Cyclin-dependent kinase 2 、 Stereochemistry 、 Protein folding 、 Cyclin-dependent kinase 、 Cyclin binding
摘要: … Comparison of the CDK2 structure in this complex with that of catalytically inactive free CDK2 (ref. 21) reveals that cyclin binding causes large conformational changes in CDK2's active …
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