Isolation of a human cyclin cDNA: Evidence for cyclin mRNA and protein regulation in the cell cycle and for interaction with p34cdc2
作者： Jonathon Pines , Tony Hunter
DOI: 10.1016/0092-8674(89)90936-7
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摘要: This paper reports the nucleotide and predicted amino acid sequence of a human B-type cyclin. The protein shows strong homology to other known cyclins in central third protein. We show that level cyclin mRNA is regulated during cell cycle, increasing G2 phase four time present G1. accumulates steadily at least 20 times its G1 abruptly destroyed mitosis. In G2/M phase, associated with p34cdc2, homolog fission yeast gene cdc2+, this complex has histone H1 kinase activity.
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