Potential Applications of Cell Cycle Manipulation to Clinical Response
作者： Ruth J. Muschel , W. Gillies McKenna
DOI: 10.1007/978-1-4615-5769-2_8
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摘要: The central organization of cellular life is the highly regulated process growth and division known as cell cycle. A normal exhibits an exquisitely system proliferation differentiation. cancer has escaped these regulatory constraints such that it able to grow proliferate without restriction. Understanding mechanisms controlling cycle in both cells may enable researchers develop more specific anticancer therapies by targeting abnormalities exhibited cell. be a state quiescence or actively cycling. Certain populations are terminally differentiated no longer have ability proliferate. These various states becoming well understood. composed four phases: G1, gap prior replication; S, synthetic phase; G2, after M, mitotic phase leading division. represents series discrete phases with continuum interdependent activity preparing for each ensuing
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