Epidermal Growth Factor Modifies Cell Cycle Control in A431 Human Squamous Carcinoma Cells Damaged by Ionizing Radiation

摘要: Epidermal growth factor (EGF) has been shown to radiosensitize A431 and other human squamous carcinoma cells with high numbers of surface EGF receptors. In this study the mechanistic basis EGF-induced radiosensitization, both ionizing radiation caused G1 phase arrests in cycling cells, but only a G2-M arrest. However, enhanced magnitude arrest, suggesting an interaction signaling pathways involved cellular responses damage. also uniquely perturbed cyclin A B1 mRNA levels during time maximum radiation-induced The effects on events probably originated G1. It is possible that aberrant signal transduction may be exploited as novel strategy for radiotherapy.