Wrapping Patterns as Universal Markers for Specificity in the Therapeutic Interference with Signaling Pathways
作者： Ariel Fernandez
DOI: 10.1007/978-3-642-11792-3_9
关键词: Signal transduction 、 Cell signaling 、 A kinase 、 Computational biology 、 Computer science 、 Kinome 、 Cell biology 、 Selectivity filter
摘要: Chapter 8 illustrated the power of wrapping concept as a guidance to engineer specificity and enhance safety in kinase inhibitor. Yet, only universal selectivity filter, applicable entire human kinome – even kinases with unreported structure would be truly useful for drug designer. This chapter thematically belongs bioinformatics realm addresses this issue at broadest possible level. The surveyed findings reveal that targeting polar dehydration patterns defined by protein dehydrons heralds new generation drugs enable tighter control specificity. universality filter field therapeutic interference cell signaling is thus established.
springer.com
sci-hub.st 参考文章(24)
Desmond G Higgins, Julie D Thompson, Toby J Gibson, USING CLUSTAL FOR MULTIPLE SEQUENCE ALIGNMENTS Methods in Enzymology. ,vol. 266, pp. 383- 402 ,(1996) , 10.1016/S0076-6879(96)66024-8
A HOPKINS, J MASON, J OVERINGTON, Can we rationally design promiscuous drugs Current Opinion in Structural Biology. ,vol. 16, pp. 127- 136 ,(2006) , 10.1016/J.SBI.2006.01.013
Morgan Huse, John Kuriyan, The Conformational Plasticity of Protein Kinases Cell. ,vol. 109, pp. 275- 282 ,(2002) , 10.1016/S0092-8674(02)00741-9
CYRUS CHOTHIA, Hydrophobic bonding and accessible surface area in proteins. Nature. ,vol. 248, pp. 338- 339 ,(1974) , 10.1038/248338A0
Ariel Fernández, Sridhar Maddipati, A priori inference of cross reactivity for drug-targeted kinases. Journal of Medicinal Chemistry. ,vol. 49, pp. 3092- 3100 ,(2006) , 10.1021/JM060163J
Jenny BAIN, Hilary McLAUCHLAN, Matthew ELLIOTT, Philip COHEN, The specificities of protein kinase inhibitors: an update. Biochemical Journal. ,vol. 371, pp. 199- 204 ,(2003) , 10.1042/BJ20021535
Miles A Fabian, William H Biggs, Daniel K Treiber, Corey E Atteridge, Mihai D Azimioara, Michael G Benedetti, Todd A Carter, Pietro Ciceri, Philip T Edeen, Mark Floyd, Julia M Ford, Margaret Galvin, Jay L Gerlach, Robert M Grotzfeld, Sanna Herrgard, Darren E Insko, Michael A Insko, Andiliy G Lai, Jean-Michel Lélias, Shamal A Mehta, Zdravko V Milanov, Anne Marie Velasco, Lisa M Wodicka, Hitesh K Patel, Patrick P Zarrinkar, David J Lockhart, A small molecule–kinase interaction map for clinical kinase inhibitors Nature Biotechnology. ,vol. 23, pp. 329- 336 ,(2005) , 10.1038/NBT1068
Xi Zhang, Alejandro Crespo, Ariel Fernández, Turning promiscuous kinase inhibitors into safer drugs Trends in Biotechnology. ,vol. 26, pp. 295- 301 ,(2008) , 10.1016/J.TIBTECH.2008.02.008
Ariel Fernández, Tobin R. Sosnick, Andrés Colubri, Dynamics of hydrogen bond desolvation in protein folding. Journal of Molecular Biology. ,vol. 321, pp. 659- 675 ,(2002) , 10.1016/S0022-2836(02)00679-4
Gerard Manning, David B Whyte, Ricardo Martinez, Tony Hunter, Sucha Sudarsanam, The Protein Kinase Complement of the Human Genome Science. ,vol. 298, pp. 1912- 1934 ,(2002) , 10.1126/SCIENCE.1075762