The Rho-Regulated ROCK Kinases in Cancer
作者： Grant R Wickman , Michael S. Samuel , Pamela A Lochhead , Michael F Olson
DOI: 10.1007/978-1-4419-1111-7_11
关键词:
摘要: The Rho-associated protein kinases ROCK I and II are central effectors for the RhoA, B, C small molecular weight GTP-binding proteins, promote actin-filament stabilization as well actin-myosin contractility. effects of on actin filaments initiate changes in cytoskeletal structure organization that critical many physiological pathological processes. has been functionally associated with cell cycle control proliferation, survival apoptosis, motility migration. Interestingly, regulation each these biological process may be significantly altered tumor cells, resulting promotion cancer progression. Extensive clinical preclinical investigations provide evidence supportive a role multiple aspects cancer, pharmacological inhibitors have developed potential anticancer chemotherapeutic agents. This chapter reviews function II, particular focus their roles cancer.
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