Targeting Rho GTPase signaling for cancer therapy.

摘要: Accumulating evidence from basic and clinical studies supports the concept that signaling pathways downstream of Rho GTPases play important roles in tumor development progression. As a result, there has been considerable interest possibility specific proteins these signal transduction could be potential targets for cancer therapy. A number inhibitors targeting critical effector proteins, activators or themselves, have developed. We will review strategies currently being used to develop kinases discuss candidate entities. Although molecularly targeted drugs inhibit GTPase not yet widely adopted use, their value as therapeutics continues drive pharmaceutical research development.