Recovery of muscle contractile function following nerve gap repair with chemically acellularized peripheral nerve grafts.

摘要: Acellular nerve grafts have emerged as a possible alternative for reconstruction of short (<2 cm) peripheral gaps. Axonal regeneration has been demonstrated within the constructs. however, very little work done to demonstrate both axonal and recovery motor function following gap repair with acellular The authors hypothesized that chemically acellularized can support provide functional reinnervation rat hindlimb muscles equivalent efficiency autografts. Peroneal nerves were harvested from adult rats acellularized. Two-- 4-cm peroneal gaps reconstructed either cellular autograft or an isograft. Functional was evaluated walking-track analyses measurement maximum tetanic isometric force (F 0 ) extensor digitorum longus (EDL) muscle. Walking-track analysis revealed no statistically significant difference in undergoing 2-cm isografts Maximum measurements 60 percent deficit EDL reinnervated by grafts, compared Four-centimeter failed any muscle reinnervation. This study demonstrates supports across gaps, may potentially serve appropriate scaffold reintroducing elements, adhesion molecules, growth factors longer