Association between polychlorinated biphenyls and diabetes mellitus in the German HELPcB cohort

摘要: Abstract Aims The aim of the present study was to examine whether there is an association between prevalence diabetes mellitus, levels HbA1c and internal PCB burden initial 263 participants HELPcB (Health Effects in High-Level Exposure PCB). Four waves follow ups were examined with a cross sectional longitudinal approach 2010 2013. surveillance program for formerly PCB-exposed workers capacitor recycling company other potentially affected people. Methods During 4 up, medical history blood samples taken. Biomonitoring conducted by gas chromatography coupled mass spectrometry. Serum analysis glucose, HbA1c, GAD, IAA, IA-2 ICA at centre laboratory diagnostics local university hospital. Results mean comparable investigations occupational cohorts like Persky et al. (2012). A logistic regression model showed higher rates comparison German general population diagnosed or undiagnosed mellitus several congeners second, third fourth quartile burden. adjusted odds ratio significantly increased 52 (7.6; 95% CI: 1.4–41.0). multiple linear significant influence on level year 3 4. development over time same applied data set 119 who met all ups. An autoantibodies no Conclusions In summary detectable glucose metabolism cohort HELPcB, however it difficult find possible mechanism congener outstanding influence. Further research more are scheduled.