Potentiation of Myocardial Ischemic Injury by Drug-Induced Taurine Depletion

摘要: The discovery that taurine treatment reverses arrhythmias associated with epinephrine- and digoxin-induced toxicity stimulated research into the myocardial actions of eventually led to hypothesis must have an important physiological function in heart (10,14, 25,28). Two subsequent lines evidence provided most compelling support for this hypothesis. First, cardiac levels are extremely high maintained by energy-dependent transport process (14,29). Second, exposure a medium containing results significant change energy calcium metabolism (5–7,15, 18,20,28).