Electrophoretic separation strategy for chiral pharmaceuticals using highly-sulfated and neutral cyclodextrins based dual selector systems

摘要: Abstract The enantiomeric separation of chiral pharmaceuticals was investigated using dual systems with mixtures cyclodextrin derivatives. systems, consisting one highly-sulfated (α-, β-, and γ-HSCD) neutral cyclodextrin, i.e. either heptakis (2,3,6-tri-O-methyl)-β-CD (TMCD), (2,6-di-O-methyl)-β-CD (DMCD) or hydroxypropyl-β-CD (HPCD), are tested on 25 pharmaceutical compounds different acid–basic properties (16 basics, 8 acids 1 neutral). influence the type concentration CD in cyclodextrins-based selector is investigated. For 11 16 basic compounds, a better obtained compared to use only CD. Mixtures TMCD give results than those DMCD HPCD. Results showed that useful achieve optimise separations not (sufficiently) separated HSCDs alone. example, ibuprofen resolved α-, β- γ-HSCD, but could be mixture 25 mM 5% HS-β-CD. Based results, based strategy defined.