Neonatal tolerance induction to Mlsa
作者： Debra J. Waite , Geoffrey H. Sunshine
DOI: 10.1016/0008-8749(88)90078-0
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摘要: Abstract We have investigated the ability of murine T cell lines to induce neonatal tolerance Mls a (minor lymphocyte stimulating). b mice were injected within 24 hr birth with MHC (major histocompatibility complex) identical generated by culturing responders from strains stimulators strains. Injected tested at 6 8 weeks age for responses in either primary mixed leukocyte reaction or IL-2 limiting dilution analysis. specific tolerant relative noninjected controls reduced 92–98% MLR and 2- 10-fold LDA. In contrast, against third-party antigens identical. Fifty percent all . These results strongly suggest that cells express gene product.
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